📋 Table of Contents
- 1. Introduction: What is Jasted Tablet?
- 2. Jasted Tablet — Dolutegravir + Emtricitabine + Tenofovir AF
- 3. USA Branded: Tivicay® + Descovy® (The $3,500/month Solution)
- 4. Jasted vs USA Branded — 99% Cost Savings
- 5. How Dolutegravir + FTC + TAF Works
- 6. Clinical Efficacy — Bioequivalent to Branded
- 7. Side Effects of Jasted Tablet
- 8. Dosage & Administration
- 9. Warnings & Precautions
- 10. Drug Interactions
- 11. Other Similar Dolutegravir-Based Regimens in India
- 12. Frequently Asked Questions (FAQs)
- 13. Conclusion: Why Choose Jasted Tablet?
- 14. References & Sources
1. Introduction: What is Jasted Tablet?
Jasted Tablet is a generic, single-tablet regimen (STR) containing three powerful antiretroviral drugs: Dolutegravir 50mg, Emtricitabine 200mg, and Tenofovir Alafenamide 25mg. This combination is recommended by the World Health Organization (WHO) as a preferred first-line treatment for HIV-1 infection in adults and adolescents.
Jasted Tablet offers a convenient once-daily dosing schedule, high efficacy, and a favorable safety profile — making it an excellent choice for patients starting antiretroviral therapy (ART) or switching from older, more toxic regimens.
Jasted Tablet Manufacturer Information:
| Detail | Information |
|---|---|
| Brand Name | Jasted Tablet |
| Manufacturer | Jasgur Life Sciences LLP |
| Active Ingredients | Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg |
| Packing | 30 Tablets per bottle |
| Price (India) | Affordable generic pricing (₹1,500-2,500 for 30 tablets) |
2. Jasted Tablet — Dolutegravir + Emtricitabine + Tenofovir AF
Jasted Tablet contains three active ingredients that work together to suppress HIV-1 replication:
| Active Ingredient | Strength | Drug Class | Mechanism | Brand Reference (USA) |
|---|---|---|---|---|
| Dolutegravir (DTG) | 50mg | Integrase Strand Transfer Inhibitor (INSTI) | Blocks HIV DNA integration into host cell | Tivicay® |
| Emtricitabine (FTC) | 200mg | Nucleoside Reverse Transcriptase Inhibitor (NRTI) | Blocks HIV replication | Part of Descovy® |
| Tenofovir Alafenamide (TAF) | 25mg | Nucleoside Reverse Transcriptase Inhibitor (NRTI) | Blocks HIV replication; safer for kidneys/bones | Descovy® |
Key Advantages of Jasted Tablet:
- Single tablet, once daily: Improves medication adherence
- High genetic barrier to resistance: Dolutegravir is less likely to develop resistance compared to older INSTIs
- Well-tolerated: Fewer neuropsychiatric side effects than Efavirenz
- Renal and bone safety: TAF is safer than older TDF
- No food restrictions: Can be taken with or without food
- Cost-effective: Affordable generic pricing in India
3. USA Branded: Tivicay® + Descovy® (The $3,500/month Solution)
In the United States, the exact same active ingredients (Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg) are available only as two separate brand-name pills: Tivicay (Dolutegravir) and Descovy (FTC + TAF).
3.1 Tivicay (Dolutegravir 50mg)
Tivicay® is manufactured by ViiV Healthcare (a subsidiary of GSK, Pfizer, and Shionogi). It was FDA-approved in 2013 and is protected by patents until 2028-2029.
3.2 Descovy (Emtricitabine + Tenofovir AF)
Descovy® is manufactured by Gilead Sciences. It was FDA-approved in 2016 and is protected by patents until 2028-2031.
3.3 Cost of Tivicay + Descovy in the USA
Because both drugs are brand-name and patent-protected, their prices are extremely high:
| Medication | Monthly Cost (Without Insurance) | Annual Cost | Patent Expiry |
|---|---|---|---|
| Tivicay 50mg (30 tablets) | ~$1,600 – $1,800 | ~$20,000 | 2028-2029 |
| Descovy (30 tablets) | ~$1,700 – $1,900 | ~$21,000 | 2028-2031 |
| Total (2 pills/day) | ~$3,300 – $3,700 | ~$40,000 – $44,000 | No single-tablet generic in USA |
4. Jasted vs USA Branded — 99% Cost Savings
Jasted Tablet offers the exact same active ingredients as Tivicay + Descovy, but at a fraction of the cost. Here’s the comparison:
| Feature | USA Branded (Tivicay + Descovy) | Jasted Tablet (Generic) | Difference |
|---|---|---|---|
| Active Ingredients | Dolutegravir 50mg + FTC 200mg + TAF 25mg | EXACTLY THE SAME | 100% identical |
| Number of Pills per Day | 2 pills (Tivicay + Descovy) | 1 pill (Jasted) | 50% fewer pills |
| Monthly Cost (USD) | ~$3,500 | ~$25-35 | 99% savings |
| Monthly Cost (INR) | ~₹2,90,000 | ~₹1,500-2,500 | 99% savings |
| Annual Cost (USD) | ~$42,000 | ~$300-420 | Save $41,000+ per year |
With Jasted Tablet, you get the same life-saving medication at 1% of the US price — without compromising on quality or efficacy.
5. How Dolutegravir + FTC + TAF Works (Mechanism of Action)
Jasted Tablet combines three antiretroviral drugs that target HIV at different stages of its replication cycle:
5.1 Dolutegravir (Integrase Strand Transfer Inhibitor — INSTI)
Dolutegravir works by inhibiting the HIV integrase enzyme, which is responsible for inserting viral DNA into the host cell’s genome. By blocking this step, Dolutegravir prevents the virus from establishing a permanent infection within the cell.
5.2 Emtricitabine (Nucleoside Reverse Transcriptase Inhibitor — NRTI)
Emtricitabine is a nucleoside analog that works by being incorporated into the growing viral DNA chain, causing chain termination. This prevents the virus from completing its replication process.
5.3 Tenofovir Alafenamide (Nucleoside Reverse Transcriptase Inhibitor — NRTI)
Tenofovir Alafenamide (TAF) is a prodrug of tenofovir that is more efficiently taken up by lymphocytes (where HIV replicates) and has lower concentrations in the bloodstream, resulting in fewer kidney and bone side effects compared to older TDF.
Result: Together, these three drugs suppress HIV viral load to undetectable levels, restore CD4 counts, and prevent disease progression to AIDS.
6. Clinical Efficacy — Bioequivalent to Branded
Jasted Tablet is a generic medication that has been tested for bioequivalence to the branded reference products (Tivicay and Descovy). Regulatory authorities (including the World Health Organization and India’s CDSCO) require generic manufacturers to demonstrate that their product releases the active ingredients into the bloodstream at the same rate and extent as the brand-name product.
Key clinical trials supporting Dolutegravir-based regimens:
- SINGLE trial (NEJM, 2013): DTG + ABC/3TC was superior to EFV/TDF/FTC (88% vs 81% viral suppression at 48 weeks)
- SPRING-2 trial: DTG was non-inferior to raltegravir
- FLAMINGO trial: DTG was superior to darunavir/ritonavir
- GEMINI studies: DTG + 3TC was non-inferior to DTG + TDF/FTC in treatment-naïve patients
7. Side Effects of Jasted Tablet
7.1 Common Side Effects (Affecting 5-10% of patients)
- Insomnia (difficulty sleeping) — most common neuropsychiatric effect
- Headache
- Nausea
- Diarrhea
- Fatigue
- Dizziness
Most side effects are mild to moderate and resolve within the first few weeks of treatment.
7.2 Less Common Side Effects
- Rash (usually mild)
- Increased creatinine (renal function monitoring recommended)
- Weight gain (especially with DTG-based regimens)
- Mood changes, depression, anxiety
- Abnormal dreams
7.3 Serious Side Effects (Require Medical Attention)
- Severe rash with fever (possible hypersensitivity reaction) — discontinue immediately
- Hepatotoxicity (liver damage) — monitor LFTs in at-risk patients
- Severe depression or suicidal ideation — seek psychiatric help
8. Dosage & Administration
Standard Dosage: One Jasted Tablet (Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg) taken orally once daily.
Administration Instructions:
- Can be taken with or without food
- Swallow whole — do not crush, chew, or break the tablet
- Take at the same time each day for best adherence
- If a dose is missed within 20 hours, take it as soon as you remember. If more than 20 hours have passed, skip the missed dose and resume regular schedule. Do not double dose.
Missed Dose Management: Missing doses can lead to viral resistance. If you frequently miss doses, speak with your healthcare provider about adherence support.
9. Warnings & Precautions
9.1 Hypersensitivity Reactions
Serious hypersensitivity reactions, including rash, fever, and organ dysfunction, have been reported with Dolutegravir-containing regimens. If you develop a rash with fever, stop Jasted immediately and seek medical attention.
9.2 Hepatitis B Co-infection
Patients co-infected with HIV and Hepatitis B virus (HBV) may experience worsening of HBV after stopping Emtricitabine or Tenofovir-containing regimens. Monitor liver function closely and consider anti-HBV therapy as needed.
9.3 Renal Impairment
Jasted Tablet contains Tenofovir Alafenamide (TAF), which is safer than older TDF but still requires monitoring in patients with pre-existing kidney disease. Dose adjustments may be needed.
9.4 Pregnancy and Breastfeeding
Dolutegravir has been associated with neural tube defects in infants born to women taking DTG at the time of conception. Women who are pregnant or planning to become pregnant should discuss treatment options with their doctor.
10. Drug Interactions
Jasted Tablet can interact with several medications. Inform your doctor about all medications you take, including over-the-counter drugs and supplements.
| Drug Class | Specific Drugs | Interaction | Recommendation |
|---|---|---|---|
| Antacids / Calcium / Iron supplements | Calcium carbonate, magnesium, iron | Can reduce Dolutegravir absorption | Take Jasted 2 hours before or 6 hours after |
| Metformin | Diabetes medication | May increase metformin levels | Monitor blood sugar; adjust metformin if needed |
| Anticonvulsants | Carbamazepine, phenytoin, phenobarbital | May reduce Dolutegravir levels | Avoid combination if possible; monitor closely |
| Rifampin | TB treatment | Significantly reduces Dolutegravir levels | Double DTG dose (50mg twice daily) recommended |
11. Other Similar Dolutegravir-Based Regimens Available in India
If Jasted Tablet is not available or your doctor recommends an alternative, the following generic single-tablet regimens containing the same active ingredients (Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg) are available in India:
| Brand Name | Manufacturer | Strength | Equivalent To | Price Range (30 tabs) |
|---|---|---|---|---|
| Jasted Tablet | Jasgur Life Sciences | 50mg/200mg/25mg | Reference product | ₹1,500-2,500 |
| Spegra Tablet | Emcure Pharmaceuticals | 50mg/200mg/25mg | Same as Jasted | ₹1,500-2,500 |
| Kocitaf Tablet | Mylan / Viatris | 50mg/200mg/25mg | Same as Jasted | ₹1,500-2,500 |
| Taffic Tablet | Hetero Healthcare | 50mg/200mg/25mg | Same as Jasted | ₹1,500-2,500 |
Note: All these products are bioequivalent to the branded reference (Tivicay + Descovy). Your doctor may prescribe any of these based on availability and cost.
12. Frequently Asked Questions (FAQs)
Q1: What is Jasted Tablet used for?
A: Jasted Tablet is used for the treatment of HIV-1 infection in adults and adolescents. It is a complete once-daily single-tablet regimen (STR) containing three antiretroviral drugs.
Q2: Is Jasted Tablet the same as Tivicay + Descovy?
A: Yes — Jasted Tablet contains the exact same active ingredients (Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg) as the US branded products Tivicay and Descovy. The only difference is that Jasted combines them into one pill.
Q3: How much does Jasted Tablet cost?
A: In India, Jasted Tablet is priced affordably (approximately ₹1,500-2,500 for 30 tablets). Compare this to the US cost of Tivicay + Descovy ($3,500/month) — that’s over 99% savings.
Q4: What are the side effects of Jasted Tablet?
A: Common side effects include insomnia, headache, nausea, diarrhea, and fatigue. Serious side effects like rash, liver problems, or mood changes require medical attention.
Q5: Can I switch from Tivicay + Descovy to Jasted Tablet?
A: Yes — because Jasted Tablet contains the exact same medications, switching is safe under medical supervision. Your doctor can advise you on the transition.
Q6: Is Jasted Tablet available outside India?
A: Jasted Tablet is manufactured in India for the Indian market. International patients may be able to purchase through authorized suppliers with a valid prescription and proper medical supervision.
Q7: Do I need a prescription for Jasted Tablet?
A: Yes — Jasted Tablet is a prescription-only medication. Always consult a qualified healthcare provider before starting or changing any HIV treatment.
Q8: How should I store Jasted Tablet?
A: Store at room temperature (below 30°C / 86°F), away from moisture and light. Keep out of reach of children.
Q9: Can I take Jasted Tablet during pregnancy?
A: Dolutegravir has been associated with neural tube defects. Pregnant women or those planning pregnancy should discuss risks and benefits with their doctor.
Q10: Does Jasted Tablet cure HIV?
A: No — there is currently no cure for HIV. Jasted Tablet suppresses the virus to undetectable levels, allowing patients to live healthy lives and prevent transmission (U=U), but it does not eliminate the virus completely.
Q11: What should I do if I miss a dose of Jasted Tablet?
A: If you miss a dose within 20 hours, take it as soon as you remember. If more than 20 hours have passed, skip the missed dose and resume your regular schedule. Do not double dose. Frequent missed doses can lead to viral resistance.
Q12: Can I take Jasted Tablet with other medications?
A: Jasted Tablet interacts with antacids, metformin, rifampin, and certain anticonvulsants. Always inform your doctor about all medications you take.
13. Conclusion: Why Choose Jasted Tablet?
Jasted Tablet offers the same life-saving active ingredients as the US branded regimen Tivicay + Descovy — but at less than 1% of the price. With once-daily dosing, high efficacy, and a favorable safety profile, Jasted Tablet is an excellent choice for HIV-1 treatment.
Key Takeaways:
- Same active ingredients: Dolutegravir 50mg + Emtricitabine 200mg + Tenofovir Alafenamide 25mg
- Single tablet, once daily: Better adherence than 2-pill regimens
- 99% cost savings: $30/month vs $3,500/month in the US
- Bioequivalent to brand-name: Same efficacy and safety profile
- Trusted manufacturer: Jasgur Life Sciences, WHO-GMP certified
Remember: Always consult your healthcare provider before starting or switching any HIV medication. This information is for educational purposes only and does not constitute medical advice.
14. References & Sources
- Walmsley SL, et al. — Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection. N Engl J Med. 2013;369(19):1807-18.
- World Health Organization (WHO) — Updated recommendations on first-line and second-line antiretroviral regimens (2024)
- US Department of Health and Human Services (DHHS) — Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV (2025)
- ViiV Healthcare — Tivicay (dolutegravir) Official Prescribing Information
- Gilead Sciences — Descovy (emtricitabine/tenofovir alafenamide) Official Prescribing Information
- European Medicines Agency (EMA) — Dolutegravir Assessment Report
- PubMed Central (PMC) — Long-term safety and efficacy of TAF versus TDF: A systematic review (2024)
- FDA (U.S. Food and Drug Administration) — Approved HIV Medicines List
⚠️ Medical Disclaimer: The information provided on this page is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting, stopping, or changing any medication.
Jasted Tablet is a prescription-only medication and should only be used under the supervision of a licensed physician. The manufacturer does not endorse or assume responsibility for the information presented here. Readers are encouraged to verify all information with their healthcare provider and official prescribing information.
Substitutes for Jasted Tablet:
🔗 Trusted Resources:
WHO HIV Treatment Guidelines |
NIH Clinical Info |
FDA HIV Resources
Last Updated: June 2026
There are no reviews yet.