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FDC ofAbacavir 600 mg . Dolutegravir 50 mg , and Lamivudine 300mg Tablet | Dolutearavir sodium is an HIV INSTI
HYPERSENSITIVITY REACTIONS, LACTIC ACIDOSIS AND SEVERE HEPATOMEGALY, AND EXACERBATIONS OF HEPATITIS B
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Serious and sometimes fatal hypersensitivity reactions have been associated with abacavir – containing products.
Hypersensitivity to abacavir samulti – organ clinical syndrome.
• Patients who carry the HLA – B * 5701 allele are at high risk for experiencing a hypersensitivity reaction to abacavir . . . . Discontinue DTG / ABC / 3TCas soon as a hypersensitivity reaction is suspected. Regardless of HLA – B * 5701 status, permanently discontinue DTG / ABC / 3TC If hypersensitivity cannot be ruled out, even when other diagnoses are possible.
• Following a hypersensitivity reaction to abacavir, NEVER restart DTGIABC / 3TCorany other abacavir-containing product. Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs. Severe acute exacerbations of hepatitis Bhave been reported in patients who are. co-infected with hepatitis B virus ( HBViana human immunodeficiency virus and have discontinued lamivudine, a component of DTG / ABC / STC. Monitor hepatic function closely in these patients and, Appropriate, Initiatoanter hepatitis B treatment