Last Updated on July 24, 2024 by admin
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Tofacitinib 5mg Cipla
About Tofajak 5mg Tablet
Side Effects – tofajak 5 mg
Tofajak 5mg Tablet is used to treat moderate to severe rheumatoid arthritis. It helps decrease pain, tenderness, and swelling in the joints by reducing inflammation. It also helps slow the progression of bone and joint damage.
Tofajak 5mg Tablet may be prescribed by itself or in combination with another medicine. The tablets can be taken with or without food and it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse.
The most common side effects of Tofajak 5mg Tablet include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have any worries about side effects, talk to your doctor.
You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Tofajak 5mg Tablet can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (such as chickenpox, measles, flu). This medicine is not suitable for children under 18 years old and you should not use it if you are pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you regularly.
USES OF TOFAJAK TABLET
BENEFITS OF TOFAJAK TABLET
Tofajak 5mg Tablet works by blocking the action of some chemicals which cause inflammation. It can help reduce pain, stiffness, and swelling in your joints and slow down the progression of bone and joint damage. This will help you do normal daily activities more easily and thus improve your quality of life. This medicine should be taken at the same time each day to get maximum benefits. Keep taking the medicine even if you feel well because it is preventing future harm as well as improving your symptoms.
SIDE EFFECTS OF TOFAJAK TABLET
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tofajak
- Upper respiratory tract infection
- Headache
- Diarrhea
- Nasopharyngitis (inflammation of the throat and nasal passages)
HOW TO USE TOFAJAK TABLET
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tofajak 5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
HOW TOFAJAK TABLET WORKS
Tofajak 5mg Tablet is a Janus kinase inhibitor. It works by blocking the action of the enzyme, Janus kinase. This decreases inflammation and joint damage in rheumatoid arthritis.
SAFETY ADVICE
Alcohol
SAFE
Consuming alcohol with Tofajak 5mg Tablet does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Tofajak 5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Tofajak 5mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
SAFE
Tofajak 5mg Tablet does not usually affect your ability to drive.
Kidney
CAUTION
Tofajak 5mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Tofajak 5mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Tofajak 5mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Tofajak 5mg Tablet may be needed. Please consult your doctor.
warning
CHILDREN CAUTION
UNSAFE
Tofajak 5mg Tablet is not recommended for use in children and adolescents below 18 years.
Tofajak 5mg Tablet Habit Forming : NO
expert advice
WHAT IF YOU FORGET TO TAKE TOFAJAK TABLET?
If you miss a dose of Tofajak 5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
See also Warning section.
Headache or diarrhea may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly.
People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.
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Tell your doctor right away if you have any serious side effects, including: unusual tiredness, fast heartbeat, shortness of breath, severe stomach/abdominal pain, signs of liver disease (such as dark urine, yellowing eyes/skin, persistent nausea/vomiting).
Tell your doctor right away if you have any signs of infection, including: fever, chills, persistent sore throat, persistent cough, night sweats, trouble breathing, painful/frequent urination, warm/red/painful skin.
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A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – tofajak 5 mg tablet
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
See also Warning section.
Before taking Tofajak 5mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (such as hepatitis B or C), kidney disease, blood/bone marrow disorders (such as anemia, low lymphocyte/neutrophil count), past/recent/current infections (such as tuberculosis, herpes zoster, HIV infection), cancer, other stomach/intestinal disorders (such as ulcers, diverticulitis), lung disease, heart disease (such as previous heart attack), blood clots, stroke.
Tofajak 5mg can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be at greater risk for infections while using this drug.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Tell your doctor if you are planning pregnancy or become pregnant.
It is unknown if this medication passes into breast milk. However, because of the possible risk to the infant, breast-feeding while using this drug and for at least 18 hours after the last dose is not recommended. Consult your doctor before breast-feeding.
Consult your pharmacist or physician.
Interactions
See also Warning section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Other medications can affect the removal of Tofajak 5mg from your body, which may affect how Tofajak 5mg works. Examples include rifampin, among others.
Does Tofajak 5mg Tablet interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Enter Medication
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Notes
Do not share this tofajak others.
Laboratory and/or medical tests (such as liver/kidney function, complete blood count, cholesterol levels, skin exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Missed Dose – tofajak 5 mg tablet
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Storage- tofajak
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
- Tofajak 5mg Tablet is used alone or in combination with other medicines for the treatment of rheumatoid arthritis, that did not improve with other anti-rheumatic drugs.
- It may take take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed.
- Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts, or cholesterol levels.
- Tofajak 5mg Tablet can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
- Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
FAQs ABOUT TOFAJAK 5MG TABLET
Q: What is TOFAJAK 5MG TABLET and why is it prescribed?
A: TOFAJAK 5MG TABLET contains tofacitinib, which belongs to the group of medicines called immunosuppressants. It is used to treat inflammatory diseases such as rheumatoid arthritis (chronic inflammatory diseases of the joints that cause pain and swelling), psoriatic arthritis (arthritis that affects people who have psoriasis), ulcerative colitis (inflammation and ulcers in the digestive tract) and ankylosing spondylitis (inflammatory disease that causes the bones in the spine to fuse).TOFAJAK 5MG TABLET is also used to treat polyarticular juvenile idiopathic arthritis and juvenile psoriatic arthritis, which cause pain and inflammation of joints in children. TOFAJAK 5MG TABLET is used together with drugs such as methotrexate when previous rheumatoid arthritis treatment was not sufficient or was not well tolerated.
Q: What should I know before starting to take TOFAJAK 5MG TABLET?
A: TOFAJAK 5MG TABLET can lower the ability of your immune system to fight infections. Do not start stating TOFAJAK 5MG TABLET if you have any kind of infection, a history of infection or are at risk of developing one. Consult with your doctor before taking TOFAJAK 5MG TABLET.
Q: Can TOFAJAK 5MG TABLET be taken by pregnant or breastfeeding women?
A: TOFAJAK 5MG TABLET is not recommended for use by pregnant or breastfeeding women. If you are a woman of childbearing age, effective birth control methods must be used during treatment with TOFAJAK 5MG TABLET and for at least 4 weeks after the last dose. Tell your doctor immediately if you become pregnant while taking TOFAJAK 5MG TABLET. Consult your doctor before taking it.
Q: Is TOFAJAK 5MG TABLET used by children?
A: TOFAJAK 5MG TABLET is used to treat polyarticular juvenile idiopathic arthritis and juvenile psoriatic arthritis, which cause pain and inflammation of joints in children over 2 years of age. Ask for your doctor’s advice before giving it to your child.
Q: Do I need to undergo routine diagnostic tests while taking TOFAJAK 5MG TABLET?
A: Your doctor might check you regularly for the levels of white blood cells and red blood cells in your blood while you take TOFAJAK 5MG TABLET. He must also check his cholesterol levels and liver and kidney functions regularly.
Q: How do I manage if I forget to take a dose of TOFAJAK 5MG TABLET?
A: If you forgot to take a dose of TOFAJAK 5MG TABLET, then do not take the missed dose between meals. Continue taking your medication as usual until your next scheduled dose and meal. Do not take a double dose of TOFAJAK 5MG TABLET to make up for a forgotten dose. Consult your doctor for advice.
Q: Can TOFAJAK 5MG TABLET be used safely on elderly patients?
A: Patients aged 65 years and older may be at increased risk of infections, heart attacks and some types of cancer; therefore, TOFAJAK 5MG TABLET should be used with caution in patients above the age of 65 years. Consult with your doctor before taking it.
REFERENCES
- R.S Satoskar, Nirmala N. Rege, S.D. Bhandarkar. Pharmacotherapy of Rheumatoid Arthritis. Pharmacology and Pharmacotherapeutics. Twenty-Fourth Edition. 2015. Page – 1637.
- Kucharz EJ, Stajszczyk M, Kotulska-Kucharz A, Batko B, Brzosko M, Jeka S, Leszczynski P, Majdan M, Olesinska M, Samborski W, Wiland P.Tofacitinib in the treatment of patients with rheumatoid arthritis: position statement of experts of the Polish Society for Rheumatology. Reumatologia. NIH National Library of Medicine, National center for biotechnology information. Pubmed. 2018. [Accessed on 28th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142023/
- Sohita Dhillon. Tofacitinib: A Review in Rheumatoid Arthritis. NIH National Library of Medicine, National center for biotechnology information. Pubmed. 2017. [Accessed on 28th July 2022] https://pubmed.ncbi.nlm.nih.gov/29139090/
- NIH National Library of Medicine, National center for biotechnology information. Pubchem. Tofacitinib. [Revised on September 2022] [Accessed on 28th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Tofacitinib
- Pfizer Manufacturing Deutschland GmbH. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 28th July 2022] https://www.medicines.org.uk/emc/files/pil.2500.pdf
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