Last Updated on September 24, 2024 by admin
INSTGRA Tablet: A Powerful Medication for Effective Treatment
INSTGRA TABLET DETAILS
INSTGRA TABLET contains Dolutegravir which belongs to the group of medicines called Integrase inhibitors. instgra Tablet is used to treat HIV (Human Immunodeficiency Virus) infection in adults, and children (aged 6 years/above) who should weigh at least 14 kg/above.
instgra Tablet is not recommended for use in patients allergic to dolutegravir.
Before taking instgra 50mg Tablet, inform your doctor if you are suffering from advanced HIV infection and/or have weak immune system (prone to serious infections), kidney problems (such as mild to severe renal impairment), and liver problems (such as mild to moderate hepatic impairment).
instgra 50mg Tablet should be used with caution during pregnancy only if it is clearly necessary since the medicine may increase the risk of birth defect (such as neural tube defect/malformed spinal cord) in unborn baby. It is generally not recommended for use in breastfeeding women as the medicine may pass through breastmilk.
instgra 50mg Tablet is not recommended for use in children (aged below 6 years) and in children who weigh less than 14 kg and who are resistant to other medicines similar to instgra Tablet. It is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking instgra Tablet are headache, stomach pain, nausea, vomiting, diarrhea, itching, and/or rash. Consult your doctor if any of the symptoms worsen.
USES OF INSTGRA TABLET
HOW INSTGRA TABLET WORKS
instgra 50mg Tablet works by reducing the amount of virus in the body which results in increased count of CD4 cell (white blood cell that helps body to fight infection) in blood treating HIV and preventing the occurrence other infections in affected individuals.
INSTGRA Tablet-Directions for Use
It is important to follow the directions provided by your healthcare professional when taking INSTGRA Tablet. The dosage and duration of treatment will depend on your specific condition and medical history. Take the tablet orally with a glass of water, with or without food, as directed by your doctor. Do not crush or chew the tablet. If you have any questions or concerns, consult your healthcare provider.
INSTGRA Tablet-Storage
Store INSTGRA Tablet at room temperature, away from direct sunlight and moisture. Keep it out of the reach of children and pets. Do not use the medication after the expiration date mentioned on the packaging. Properly discard any unused medication.
INSTGRA Tablet-Drug Warnings
Before taking INSTGRA Tablet, inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. This will help prevent any potential drug interactions or adverse effects. It is essential to disclose your complete medical history to ensure the safe and effective use of this medication.
INSTGRA Tablet-Drug Interactions
INSTGRA Tablet may interact with certain medications, supplements, or herbal products. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. This will help prevent any potential drug interactions and ensure the safe use of INSTGRA 50MG Tablet.
INSTGRA Tablet-Drug Interactions Checker List: Safety Advice
When taking INSTGRA Tablet, consider the following safety advice:
- Avoid consuming alcohol while on this medication as it may increase the risk of side effects.
- Inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.
- Follow the prescribed dosage and do not exceed it without consulting your doctor.
- If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
- Do not stop taking INSTGRA Tablet abruptly without consulting your healthcare provider.
SIDE EFFECTS OF INSTGRA TABLET
- COMMON
- Headache
- Stomach pain, nausea, vomiting, diarrhea, wind
- Rash, itching,
- Stomach pain/discomfort
- Sleeplessness, dizziness
- Abnormal dreams, depression, anxiety
- Lack of energy (fatigue)
UNCOMMON
- Inflammation of the liver (hepatitis)
- Suicide attempt, suicidal thoughts
- Joint/muscle pain
RARE
- Signs of liver failure such as yellowing of skin and the whites of the eyes/unusually dark urine.
- Stop taking instgra Tablet and contact your doctor immediately if you experience any of the following side effects:
- Signs of allergic reactions such as skin rash, fever, lack of energy, swelling of face/mouth, difficulty in breathing, and/or muscle/joint aches
- Signs of infection such as fever, chills, shortness of breath, and/or nasal congestion
HOW TO MANAGE SIDE EFFECTS
Headache:
If instgra Tablet causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking instgra Tablet. If it lasts more than a week or becomes severe, then consult and inform your doctor.
Nausea and vomiting:
Take instgra Tablet with/just after a meal. Stick to simple meals. Avoid eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom worsens.
Rashes:
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
instgra Tablet should be used with caution during pregnancy only if it is clearly necessary since the medicine may increase the risk of birth defect (such as neural tube defect/malformed spinal cord) in unborn baby. Women of childbearing potential should use contraceptive measures (such as condoms/pills) while in treatment with instgra Tablet to prevent pregnancy and should inform doctor immediately if accidental pregnancy occurs. Consult your doctor before taking the medicine.
BREASTFEEDING
instgra Tablet is generally not recommended for use in breastfeeding women as the medicine may pass through breastmilk. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
Do not drive or operate machines, if you feel dizzy or have other side effects that make you less alert after taking instgra Tablet.
ALCOHOL
Avoid consumption of alcohol while taking instgra Tablet since it may increase the risk of occurrence of osteonecrosis (segmental bone death due to impaired blood supply).
KIDNEY
instgra 50mg Tablet should be taken with caution in patients with kidney problems such as mild, moderate/severe renal impairment. Consult your doctor before taking instgra Tablet.
LIVER
instgra 50mg Tablet should be used with caution in patients with liver problems such as mild to moderate hepatic impairment. Consult your doctor before taking instgra Tablet.
CHILDREN CAUTION
UNSAFE
instgra Tablet is not recommended for use in children and adolescents below 18 years.
instgra Tablet
Habit Forming
INSTGRA Tablet is not habit-forming. However, it is important to use this medication as prescribed by your healthcare provider and not exceed the recommended dosage.
ALLERGY
Do not take instgra 50mg Tablet if you are allergic to Dolutegravir, and/or any other ingredients of this medicine.
OTHERS
Before taking instgra Tablet, inform your doctor if you:
Are suffering from advanced HIV infection and have weak immune system with prone to develop serious infections.
Use in Pediatrics:
instgra Tablet is not recommended for use in children (aged below 6 years) and in children who weigh less than 14 kg and who are resistant to other medicines similar to instgra Tablet. Consult your doctor before taking instgra 50mg Tablet.
Use in Geriatrics:
instgra 50mg Tablet should be used with caution in elderly patients (aged 65 years/ above). Consult your doctor before taking instgra Tablet.
INTERACTIONS
A. Drug – Drug interactions:
Before taking instgra 50mg Tablet, inform your doctor if you are taking any of the following medicine:
- Fampridine (used to treat multiple sclerosis)
- Metformin (used to treat diabetes)
- Antacids (used to treat indigestion and heartburn)
- Calcium supplements, iron supplements, and multivitamins
- Etravirine, efavirenz, fosamprenavir/ritonavir, nevirapine or tipranavir/ritonavir
- (used to treat HIV infection)
- Rifampicin (used to treat tuberculosis and other bacterial infections)
- Phenytoin, phenobarbital (used to treat epilepsy)
- Oxcarbazepine, carbamazepine (treat epilepsy/bipolar disorder)
- St. John’s wort (herbal medicine used to treat depression)
INSTGRA Tablet-Overdosage:
If you or anyone else accidentally take too much of instgra Tablet, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
SYNOPSIS
Drug : Dolutegravir 50mg
Pharmacological Category : Integrase inhibitor
Therapeutic Indication : HIV infection
Dosage Forms : Tablet
MORE INFORMATION
- Keep INSTGRA TABLET out of reach of children
- Store INSTGRA TABLET at room temperature
FOOD AND DRINK
FOOD AND DRINK- Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
- Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry, or seafood.
- Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
- Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
- Drink more fluids and avoid alcoholic beverages to prevent dehydration.
Wash your hands properly before and after eating. - Make sure you sleep at least 8 hours a day.
FAQ for Instgra Tablet
Here are 35 frequently asked questions about instgra 50mg (Dolutegravir) along with their answers:
1. What is instgra 50mg used for?
A: instgra 50mg is an antiretroviral medication used to treat HIV-1 infection in adults and children weighing at least 30 kg, often in combination with other medications.
2. When is the best time to take instgra 50mg?
A: instgra 50mg is taken once or twice daily, depending on your prescription. It can be taken with or without food.
3. What are the long-term side effects of instgra 50mg?
A: Long-term side effects may include:
- Liver problems
- Weight gain
- Increased cholesterol
- Mental health issues like depression or anxiety in some people.
4. Can you provide a review of instgra 50mg?
A: instgra 50mg is generally well-reviewed for its effectiveness and tolerability, with many patients finding it easy to take. However, some users report side effects like insomnia or fatigue.
5. What are the common uses of instgra 50mg?
A: instgra 50mg is commonly used to:
- Lower viral load in people living with HIV.
- Boost the immune system by increasing CD4 cell counts.
6. What is the recommended dosage of instgra 50mg?
A: The dosage depends on whether you are treatment-naive or treatment-experienced and other medications you are taking. Usually, it’s 50 mg once or twice daily.
7. Is instgra 50mg safe to use?
A: Yes, instgra 50mg is considered safe when prescribed. However, it requires monitoring, especially in people with pre-existing liver conditions or those taking other medications.
8. Does instgra 50mg cure HIV?
A: No, instgra 50mg does not cure HIV but helps to control the virus, preventing it from multiplying and reducing the risk of AIDS.
9. Is instgra 50mg safe in pregnancy?
A: instgra 50mg can be used in pregnancy, but caution is advised, especially during the first trimester, due to a potential risk of neural tube defects.
10. Can instgra 50mg be used in children?
A: Yes, instgra 50mg is approved for use in children weighing 30 kg (66 lbs) or more.
11. What if I miss a dose of instgra 50mg?
A: Take the missed dose as soon as you remember, unless it is near the time for your next dose. Do not take a double dose to make up for a missed one.
12. Can I stop taking instgra 50mg if I feel better?
A: No, you should not stop taking instgra 50mg without consulting your healthcare provider, as this can lead to viral resistance and treatment failure.
13. What are the uses of instgra 50mg?
A: instgra 50mg is primarily used to manage HIV-1 infection by helping to lower the viral load and improve the immune system.
14. Are there alternative medications to instgra 50mg?
A: Yes, alternatives include Biktarvy, Genvoya, and Triumeq (which also contains dolutegravir, like instgra 50mg).
15. Can instgra 50mg interact with other medications?
A: Yes, instgra 50mg can interact with drugs like:
- Metformin
- Carbamazepine
- Rifampin
- St. John’s wort
Always inform your healthcare provider about all medications you are taking.
16. How long does it take for instgra 50mg to show results?
A: instgra 50mg usually begins lowering viral load within 2 to 4 weeks of starting treatment.
17. What precautions should be taken while using instgra 50mg?
A: Monitor liver function, especially if you have Hepatitis B or C. Also, report any mental health changes like depression or anxiety to your doctor.
18. Where can I get more information about instgra 50mg?
A: More information can be found on reputable sources like Drugs.com or through your healthcare provider.
19. What is the success rate of instgra 50mg?
A: instgra 50mg has a high success rate, with over 90% of people achieving undetectable viral loads when used as part of combination therapy.
20. Can instgra 50mg cause weight gain?
A: Yes, weight gain has been reported, particularly in patients using integrase inhibitors like dolutegravir, the active ingredient in instgra 50mg.
21. Can instgra 50mg cause liver problems?
A: Yes, instgra 50mg may cause liver problems, especially in people with Hepatitis B or C or pre-existing liver conditions.
22. Does instgra 50mg require genetic testing?
A: No genetic testing is required before starting instgra 50mg, but regular monitoring of liver function is important.
23. What are the signs of a hypersensitivity reaction to instgra 50mg?
A: Symptoms of a hypersensitivity reaction include:
- Fever
- Rash
- Nausea
- Breathing difficulties
Seek medical help immediately if these symptoms occur.
24. Does instgra 50mg interact with alcohol?
A: While instgra 50mg does not directly interact with alcohol, excessive alcohol use can increase the risk of liver damage.
25. Can instgra 50mg cause kidney problems?
A: While instgra 50mg is generally safe for the kidneys, it can cause increased creatinine levels. Regular monitoring is advised.
26. Can I take antacids with instgra 50mg?
A: Antacids containing magnesium or aluminum should be taken 2 hours before or 6 hours after instgra 50mg to avoid reducing its effectiveness.
27. Does instgra 50mg affect mental health?
A: Some people taking instgra 50mg have reported side effects such as depression, anxiety, or suicidal thoughts. Report any mood changes to your healthcare provider.
28. Is instgra 50mg effective in people with a low CD4 count?
A: Yes, instgra 50mg can be effective even in patients with low CD4 counts, helping to increase these levels over time.
29. What is lactic acidosis, and is it linked to instgra 50mg?
A: Lactic acidosis is a rare but serious condition where lactate builds up in the blood. It can cause muscle pain, weakness, and difficulty breathing.
30. Can I take instgra 50mg if I have Hepatitis B?
A: instgra 50mg can be used in patients with Hepatitis B, but careful monitoring is necessary due to the risk of liver complications.
31. Can instgra 50mg be used as PrEP?
A: No, instgra 50mg is not approved for use as pre-exposure prophylaxis (PrEP). Other medications like Truvada are used for PrEP.
32. Can I travel with instgra 50mg?
A: Yes, you can travel with instgra 50mg. Keep it in your carry-on luggage and ensure you have enough medication for the trip.
33. What lifestyle changes should I make while taking instgra 50mg?
A: A balanced diet, regular exercise, and avoiding excessive alcohol can help reduce the risk of side effects and improve your overall health.
34. Does instgra 50mg affect fertility?
A: There is no evidence that instgra 50mg affects fertility in men or women.
35. Can I take instgra 50mg with other HIV medications?
A: instgra 50mg is often combined with other HIV medications, but it should not be combined with other drugs that contain dolutegravir to avoid overdose.
36. what is instgra Tablet price in india?
A: Its MRP is already reduced but you can get it very cheaply @2399 with long expiry And free shipping + cash on delivery service available on hivhub.in
These FAQs cover key aspects of instgra 50mg for HIV treatment, offering essential guidance on how to use and manage the medication safely.
REFERENCES:
- Charles W. Flexner. Antiretroviral agents and treatment of HIV infection. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 1137-1157.
- Dolutegravir. NIH National Library of Medicine. National Center for Biotechnology Information. PubChem. December 2022. [Accessed on 21st December 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Dolutegravir
- Perrine Courlet, Felix Stader, Monia Guidi, Susana Alves Saldanha, Marcel Stoeckle, Matthias Cavassini, Manuel Battegay, Thierry Buclin, Laurent Arthur Decosterd, Catia Marzolini; Swiss HIV Cohort Study. Pharmacokinetic profiles of boosted darunavir, dolutegravir and lamivudine in aging people living with HIV. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. January 2020. [Accessed on 21st December 2022] https://pubmed.ncbi.nlm.nih.gov/31490233/
- Dennis J. Cada, Terri L. Levien, Danial E. Baker. Dolutegravir. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. February 2014. [Accessed on 21st December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940684/
- Glaxo Wellcome, S.A. Electronic Medicines Compendium (EMC). [Revised in June 2022] [Accessed on 21st December 2022] https://www.medicines.org.uk/emc/files/pil.10057.pdf
- Drugs.com – Tivicay
- FDA.gov – Tivicay Information
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