Siromus 1mg Tablet


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Last Updated on January 16, 2024 by admin

About Siromus 1mg

Sirolimus (1mg)

Siromus Tablet is used for prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ.

Siromus 1mg must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of Siromus Tablet may have serious side effects on the body.

Common side effects of Siromus 1mg include edema, Increased blood lipid level, high blood pressure, increased level of creatinine, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and thrombocytopenia. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions such as rash, shortness of breath, coughing, swelling, etc.

Before taking this Siromus Tablet, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. If you notice signs of infection, any changes in the appearance or size of a mole, unusual growths or lumps, or unusual tiredness or weakness during the treatment, you must consult the doctor immediately.



  • In Prevention of kidney transplant rejection

Siromus Tablet is used with other medications to prevent kidney transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving kidney transplants. This Siromus Tablet reduces the activity of a person’s own immune system and prevents any such rejection.


Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Siromus 1mg

  • Nausea
  • Increased blood lipid level
  • Low blood platelets
  • Headache
  • Abdominal pain
  • Fever
  • Anemia (low number of red blood cells)
  • Urinary tract infection
  • Diarrhea
  • High blood pressure
  • Increased creatinine level in blood
  • Joint pain
  • Edema (swelling)


Take Siromus Tablet in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Siromus Tablet may be taken with or without food, but it is better to take it at a fixed time.


Siromus Tablet is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.


alcohol warning   Alcohol
It is not known whether it is safe to consume alcohol with Siromus Tablet. Please consult your doctor.

Pregnancy care   Pregnancy
Siromus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Siromus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Siromus Tablet does not usually affect your ability to drive.

kidney warning   Kidney
Siromus Tablet is safe to use in patients with kidney disease. No dose adjustment of Siromus Tablet is recommended.

Siromus Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Siromus Tablet may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild to moderate liver disease.


baby warning   CHILDREN CAUTION
Siromus Tablet is not recommended for use in children and adolescents below 18 years.

   expert advice

  • Siromus Tablet is used to prevent organ rejection following a kidney transplant operation.
  • Avoid grapefruit juice while you are on treatment with this medicine. This is because a chemical in grapefruit juice increases the amount of Siromus Tablet in your bloodstream. This makes side-effects more likely.
  • There is a possibility of a slight increase in the risk of skin cancer with Siromus Tablet. Do not use sunbeds, and avoid strong sunlight or use a sun cream with a high sun protection factor (SPF of at least 15).
  • If you have diabetes mellitus, Siromus Tablet may affect your blood sugar levels. Monitor your sugar level regularly and report any extreme changes to your doctor.


  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry, or seafood.
  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration.
    Wash your hands properly before and after eating.
  • Make sure you sleep at least 8 hours a day.


Q: Does SIROMUS 1MG affect male fertility?

A: Decreased sperm count has been associated with the use of SIROMUS TABLET and it usually returns to normal once treatment is discontinued. Consult your doctor for further queries.

Q: What if I miss a dose of SIROMUS 1MG?

A: If you miss a dose of SIROMUS TABLET, take it as soon as you remember. However, skip that dose if it’s almost time for the next one. Do not take SIROMUS TABLET two times to make up for the missed dose. Remember to always take SIROMUS TABLET and ciclosporin approximately 4 hours apart.

Q: Can I stop taking SIROMUS 1MG on my own?

A: Do not stop taking SIROMUS TABLET unless your doctor tells you to, as doing so might increase the risk of losing your transplant. Consult your doctor for further queries.

Q: What are the precautionary measures to follow while taking SIROMUS 1MG?

A: Do not drink grapefruit juice while taking SIROMUS TABLET. Inform your doctor if you have liver problem, body mass index more than 30 kg/m2, intolerance to certain sugars or had a previously failed kidney transplant. Patients should also tell if they are pregnant, breast-feeding or allergic to anything.

Q: Can SIROMUS 1MG be given to children?

A: No. SIROMUS TABLET is used for adults and not recommended for children and adolescents below 18 years of age. Consult your child’s doctor for advice. The physician will determine a proper dose or select a suitable alternative treatment for your child.


  1. KD Tripathi. Immunosuppressant Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 941.
  2. Augustine JJ, Bodziak KA, Hricik DE. Use of sirolimus in solid organ transplantation. NIH National Library of Medicine, National center for biotechnology information. 2007. [Accessed on 20th June 2022].
  3. C G Groth, L Bäckman, J M Morales, R Calne, H Kreis, P Lang, J L Touraine, K Claesson, J M Campistol, D Durand, L Wramner, C Brattström, B Charpentier. Sirolimus (rapamycin)-based therapy in human renal transplantation. NIH National Library of Medicine, National center for biotechnology information. April 1999. [Accessed on 20th June 2022].
  4. Pfizer Ireland Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 20th June 2022].
  5. Wyeth Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 20th June 2022].,021110s076lbl.pd

Substitutes for Siromus 1mg Tablet

Rapacan 1mg Tablet

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