📋 Table of Contents
- 1. Introduction: What is Lenabuzz 25mg Capsule?
- 2. Lenabuzz 25mg — Lenalidomide for Blood Cancer Treatment
- 3. Uses of Lenabuzz 25mg Capsule
- 4. How Lenabuzz 25mg Capsule Works (Mechanism of Action)
- 5. Dosage & Administration of Lenabuzz 25mg Capsule
- 6. Side Effects of Lenabuzz 25mg Capsule
- 7. Warnings & Precautions
- 8. Drug Interactions
- 9. Lenabuzz 25mg Price in India — Online & Offline
- 10. Substitutes for Lenabuzz 25mg Capsule
- 11. Frequently Asked Questions (FAQs)
- 12. Conclusion
- 13. References & Medical Disclaimer
1. Introduction: What is Lenabuzz 25mg Capsule?
Lenabuzz 25mg Capsule is a prescription-based anti-cancer medication manufactured by Jasgur Life Sciences LLP, a trusted pharmaceutical company based in India. This medicine contains Lenalidomide 25mg as its active pharmaceutical ingredient, which belongs to a class of drugs known as immunomodulatory agents or IMiDs (Immunomodulatory Imide Drugs).
Lenabuzz 25mg Capsule is primarily used in the treatment of various hematological (blood-related) cancers, including Multiple Myeloma and Myelodysplastic Syndromes (MDS). The 25mg strength is typically used for the treatment of multiple myeloma in combination with dexamethasone.
Lenabuzz 25mg Capsule Manufacturer Information:
| Detail | Information |
|---|---|
| Brand Name | Lenabuzz 25mg Capsule |
| Manufacturer | Jasgur Life Sciences LLP |
| Active Ingredient | Lenalidomide 25mg |
| Packing | 30 Capsules per bottle (Lenabuzz 25mg 30’s) |
| Storage | Store below 30°C |
2. Lenabuzz 25mg — Lenalidomide for Blood Cancer Treatment
Lenabuzz 25mg Capsule contains Lenalidomide, which is a structural derivative of thalidomide, designed to enhance immunomodulatory properties while minimizing side effects. It is available as Lenabuzz 25mg Capsule — each capsule containing 25mg of Lenalidomide.
The 25mg strength is the maximum single-capsule dose and is primarily used for the treatment of multiple myeloma, especially in combination with dexamethasone for patients who are newly diagnosed (transplant ineligible) or have relapsed/refractory disease.
Available Strengths of Lenabuzz:
- Lenabuzz 10mg Capsule — Standard dosing for MDS, maintenance therapy
- Lenabuzz 25mg Capsule — Maximum dose for aggressive multiple myeloma
Lenabuzz 25mg JASGUR LIFESCIENCES is a WHO-GMP certified generic product, bioequivalent to the branded reference product Revlimid® (Bristol-Myers Squibb).
3. Uses of Lenabuzz 25mg Capsule
Lenabuzz 25mg Capsule uses include the treatment of several serious hematological conditions:
3.1 Multiple Myeloma (MM)
Multiple myeloma is a cancer of plasma cells—a type of white blood cell found in the bone marrow. The 25mg strength is specifically indicated for:
- Newly Diagnosed Multiple Myeloma (Transplant Ineligible): In combination with dexamethasone — Lenabuzz 25mg Capsule taken once daily on days 1-21 of each 28-day cycle
- Relapsed/Refractory Multiple Myeloma: In combination with dexamethasone for patients who have received at least one prior therapy
3.2 Myelodysplastic Syndromes (MDS)
For MDS with deletion 5q, the standard dose is 10mg (not 25mg). However, some protocols may use higher doses under strict medical supervision.
Lenabuzz 25mg Capsule benefits include high efficacy, once-daily dosing, and improved quality of life for multiple myeloma patients.
4. How Lenabuzz 25mg Capsule Works (Mechanism of Action)
How does Lenabuzz 25mg Capsule work? Lenalidomide, the active ingredient in Lenabuzz 25mg Capsule, works through multiple mechanisms:
4.1 Direct Anti-cancer Activity
- Induces cell cycle arrest (stops cancer cells from dividing)
- Promotes apoptosis (programmed cell death) of malignant cells
- Downregulates key transcription factors like IRF4 and MYC
4.2 Immunomodulatory Effects (Enhancing Immune System)
- Enhances T-cell and NK-cell (Natural Killer cell) activation
- Increases IL-2 and IFN-γ production
- Stimulates the body’s own immune system to recognize and attack cancer cells
4.3 Anti-angiogenic Effects (Starving the Tumor)
- Inhibits the growth of new blood vessels (angiogenesis)
- Tumors need new blood vessels to grow and spread
- By blocking this process, Lenabuzz effectively “starves” the cancer
5. Dosage & Administration of Lenabuzz 25mg Capsule
Lenabuzz 25mg dosage varies based on the condition being treated, renal function, and individual tolerance.
5.1 Recommended Dosage for Multiple Myeloma
For newly diagnosed (transplant ineligible) and relapsed/refractory multiple myeloma:
- Lenabuzz 25mg once daily on days 1-21 of each 28-day cycle
- In combination with dexamethasone 40mg once daily on days 1, 8, 15, and 22 of each 28-day cycle
- Duration: Until disease progression or unacceptable toxicity
5.2 How to Take Lenabuzz 25mg Capsule
- Swallow whole — do not break, chew, or open the capsule
- Can be taken with or without food
- Take at approximately the same time each day
- If a dose is missed within 12 hours, take immediately. If more than 12 hours have passed, skip and take next dose at regular time. Do not double dose.
- Maintain adequate hydration during treatment
5.3 Dose Adjustments for Renal Impairment
| Renal Function (CrCl) | Recommended Dose |
|---|---|
| Normal (≥60 mL/min) | 25mg once daily |
| Moderate (30-59 mL/min) | 10mg once daily |
| Severe (15-29 mL/min) | 5mg once daily (or 10mg every other day) |
| End-stage renal disease (ESRD) on dialysis | 5mg once daily (administer after dialysis) |
6. Side Effects of Lenabuzz 25mg Capsule
Lenabuzz 25mg Capsule side effects can be categorized by frequency and severity.
6.1 Very Common Side Effects (Affecting >10% of patients)
| Side Effect | Incidence | Management |
|---|---|---|
| Fatigue/Weakness | 60-70% | Rest, nutrition, adjust daily activities |
| Neutropenia (low white blood cells) | 50-60% | Regular blood monitoring, growth factors if needed |
| Thrombocytopenia (low platelets) | 40-50% | Bleeding precautions, platelet transfusions if needed |
| Anemia (low red blood cells) | 30-40% | Blood transfusions, erythropoiesis-stimulating agents |
| Diarrhea | 30-40% | Anti-diarrheal medications, hydration |
6.2 Serious Side Effects (Require Immediate Medical Attention)
- Deep Vein Thrombosis (DVT): Leg swelling, pain, warmth
- Pulmonary Embolism (PE): Sudden shortness of breath, chest pain
- Severe neutropenia with fever: Fever, chills, signs of infection
- Stevens-Johnson Syndrome: Widespread rash, blisters, mouth ulcers
- Tumor Lysis Syndrome: Nausea, vomiting, muscle cramps, irregular heartbeat
7. Warnings & Precautions
7.1 Embryo-Fetal Toxicity (Pregnancy Prevention Program) — Critical Warning
ABSOLUTELY CRITICAL WARNING: Lenalidomide (Lenabuzz 25mg Capsule) is STRUCTURALLY RELATED TO THALIDOMIDE, which is known to cause severe, life-threatening birth defects when taken during pregnancy.
For Women of Childbearing Potential:
- Must have two negative pregnancy tests before starting treatment
- Must use two effective forms of contraception simultaneously
- Contraception must be used for at least 4 weeks before, during, and for 4 weeks after treatment
For Men: Must use latex condoms during any sexual contact with a woman of childbearing potential. Do not donate sperm during treatment and for 4 weeks after treatment.
Blood Donation Restriction: Patients taking Lenabuzz must NOT donate blood during treatment and for 4 weeks after stopping treatment.
8. Lenabuzz 25mg Price in India — Online & Offline
Lenabuzz 25mg price is significantly lower than the branded version (Revlimid®). Here’s the pricing information:
| Product | Strength | Packing | Price (INR) |
|---|---|---|---|
| Lenabuzz 25mg Capsule | 25mg | 30 capsules (1 bottle) | ₹2,500 – ₹3,500 |
| Lenabuzz 25mg online price | 25mg | 30 capsules | ₹2,500 – ₹3,500 |
| Lenabuzz 25mg JASGUR LIFESCIENCES price | 25mg | 30 capsules | ₹2,500 – ₹3,500 |
9. Frequently Asked Questions (FAQs)
Q1: What is Lenabuzz 25mg Capsule used for?
A: Lenabuzz 25mg Capsule uses include the treatment of multiple myeloma (a type of blood cancer), especially in combination with dexamethasone.
Q2: What is the price of Lenabuzz 25mg Capsule in India?
A: Lenabuzz 25mg price is approximately ₹2,500-₹3,500 for 30 capsules.
Q3: Is Lenabuzz 25mg Capsule available online?
A: Yes, Lenabuzz 25mg online is available through authorized online pharmacies with a valid prescription.
Q4: What are the side effects of Lenabuzz 25mg Capsule?
A: Common Lenabuzz 25mg Capsule side effects include fatigue, neutropenia, thrombocytopenia, diarrhea, nausea, and rash.
Q5: Who manufactures Lenabuzz 25mg Capsule?
A: Lenabuzz 25mg JASGUR LIFESCIENCES is manufactured by Jasgur Life Sciences LLP.
Q6: Can I take Lenabuzz 25mg Capsule during pregnancy?
A: NO. This medicine causes severe birth defects. Women of childbearing potential must use two effective forms of contraception.
Q7: What is Lenabuzz 25mg Capsule dosage?
A: The standard Lenabuzz 25mg dosage is one capsule once daily on days 1-21 of each 28-day cycle.
Q8: What is Lenabuzz 25mg Capsule composition?
A: Lenabuzz 25mg Capsule composition includes Lenalidomide 25mg as the active ingredient.
Q9: How many capsules are in a Lenabuzz 25mg 30’s bottle?
A: Lenabuzz 25mg 30’s means one bottle contains 30 capsules.
Q10: Is Lenabuzz 25mg Capsule safe for the elderly?
A: Yes, but dose adjustment may be needed based on kidney function. Regular blood monitoring is essential.
10. Conclusion
Lenabuzz 25mg Capsule is a highly effective, generic alternative to branded Revlimid for the treatment of multiple myeloma. The 25mg strength is specifically indicated for combination therapy with dexamethasone.
Key Takeaways:
- Same active ingredient: Lenalidomide 25mg — bioequivalent to Revlimid®
- Affordable price: Significantly lower than branded version
- Once-daily dosing: Convenient dosage schedule
- Available online: With valid prescription
- Trusted manufacturer: Jasgur Life Sciences — WHO-GMP certified
⚠️ Medical Disclaimer: This information is for educational purposes only. Always consult a qualified healthcare professional before starting or changing any medication. Lenabuzz 25mg Capsule is a prescription-only medication.
Last Updated: June 2026
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