Description: Jastinib 5mg Tablet
Overview: Jastinib 5mg Tablet
Jastinib 5mg Tablet is a targeted cancer medicine (tyrosine kinase inhibitor). It is prescribed to treat advanced renal cell carcinoma (RCC) – a type of kidney cancer. It works by blocking the growth of blood vessels that feed the tumor, thereby slowing down the spread of cancer.
Jastinib is usually given when other treatments (like sunitinib or cytokines) have not worked well. Take this medicine exactly as prescribed by your oncologist, usually twice daily with a gap of 12 hours. It can be taken with or without food, but consistently the same way each time.
Common side effects include diarrhea, high blood pressure, fatigue, nausea, loss of appetite, and weight loss. These are manageable but inform your doctor if they become severe. Jastinib can also cause hoarseness, joint pain, and rash. Regular monitoring of blood pressure, thyroid function, and liver enzymes is required.
Do not take Jastinib if you are pregnant or planning pregnancy – it can harm the unborn baby. Both men and women should use effective contraception during treatment and for at least 1 week after the last dose. Avoid grapefruit and grapefruit juice as they interfere with how Jastinib works in the body.
Before starting treatment, tell your doctor if you have liver disease, kidney disease (not cancer-related), high blood pressure, bleeding problems, or a history of stroke or heart attack.
Jastinib 5mg Tablet – Medicinal Benefits
Jastinib works by inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). By blocking these receptors, it prevents angiogenesis (formation of new blood vessels) that tumors need to grow and spread. This helps shrink the kidney tumor or slow its progression.
Jastinib 5mg Tablet – Storage
Store at room temperature (20°C to 25°C), away from moisture and heat. Keep the bottle tightly closed. Do not use if the tablet appearance has changed. Keep out of reach of children and pets.
Jastinib 5mg Tablet – Drug Interactions
Jastinib may interact with other medications. Inform your doctor about all prescription drugs, OTC medicines, and herbal supplements you are taking.
Jastinib 5mg Tablet – Drug Interactions Checker List
Ketoconazole / Itraconazole – Increases Jastinib levels, risk of toxicity. Dose reduction may be needed.
Rifampin / Rifabutin – Decreases Jastinib levels, reduces effectiveness. Avoid or adjust dose.
Grapefruit / Grapefruit juice – Increases Jastinib blood levels. Avoid completely.
St. John’s Wort – Decreases Jastinib levels. Do not use.
Blood pressure medications – Jastinib raises BP; your BP meds may need adjustment.
Jastinib 5mg Tablet – Safety Advice
Monitor blood pressure regularly – Jastinib commonly causes hypertension. Report high readings to your doctor.
Do not drive if you feel dizzy or extremely tired – Use caution.
Avoid grapefruit and grapefruit juice for the entire duration of treatment.
Use effective contraception – For men and women during and for 1 week after last dose.
Report any signs of bleeding (unusual bruising, blood in urine/stool, coughing blood) immediately.
Jastinib 5mg uses
- Advanced kidney cancer
Product Benefits
Jastinib is used for second-line treatment of advanced renal cell carcinoma (kidney cancer that has spread to other parts of the body). It helps:
Shrink tumors or slow their growth
Improve progression-free survival
Manage symptoms when other treatments have failed
It is not a cure for kidney cancer, but it can help control the disease. Take it exactly as prescribed. Missing doses may reduce effectiveness.
Side Effects of Jastinib 5mg Tablet
Most side effects are manageable. Consult your doctor if they persist or become severe.
Common side effects:
Diarrhea (most common)
High blood pressure
Fatigue / weakness
Nausea and vomiting
Decreased appetite / weight loss
Hoarseness (voice changes)
Joint pain or muscle pain
Rash or dry skin
Cough or shortness of breath
Low thyroid function (hypothyroidism)
Mouth sores (stomatitis)
Hand-foot skin reaction (redness, swelling on palms/soles)
How to Use Jastinib 5mg Tablet
Take Jastinib exactly as prescribed by your doctor. Swallow the tablet whole with water. Do not crush, chew, or break it. Take it twice daily (approximately every 12 hours) with or without food, but be consistent (always with food or always without).
If you vomit after taking a dose, do not take an extra dose – wait for the next scheduled dose.
How Jastinib 5mg Tablet Works
Axitinib is a tyrosine kinase inhibitor (TKI). It blocks the activity of vascular endothelial growth factor receptors (VEGFRs). These receptors are like “on switches” that tell blood vessels to grow around a tumor. By blocking them, Axitinib cuts off the blood supply that the cancer needs to grow and survive.
Safety Advice
| 🍷⚠️ | ALCOHOL – CAUTION Avoid or limit alcohol as it may increase liver strain. |
| 🤰🚫 | PREGNANCY – UNSAFE Do not use during pregnancy. Effective contraception required. |
| 🤱❌ | BREASTFEEDING – NOT RECOMMENDED Do not breastfeed during treatment and for 2 weeks after last dose. |
| 🚗⚠️ | DRIVING – CAUTION May cause fatigue, dizziness, or low BP. Drive only if alert. |
| 🩺✅ | KIDNEY DISEASE – SAFE WITH MONITORING Dose adjustment may be needed. |
| 🫀⚠️ | LIVER DISEASE – CAUTION Severe liver impairment requires dose reduction or alternative. |
| 🧒🚫 | CHILDREN – NOT RECOMMENDED Safety not established under 18 years. |
| 💊✅ | HABIT FORMING – NO No dependence or addiction potential. |
Expert Advice / What If You Forget a Dose?
If you miss a dose by less than 6 hours, take it as soon as you remember.
If it’s almost time for your next dose (within 6 hours), skip the missed dose and take the next one on schedule.
Do not double the dose to make up for a missed one.
FAQs ABOUT Jastinib 5MG TABLET
Q1: Can Jastinib cure kidney cancer?
A: No, Jastinib is not a cure. It helps control advanced kidney cancer by slowing tumor growth and improving quality of life.
Q2: What is the price of Jastinib 5mg tablet in India?
A: The price ranges from ₹1,599 to ₹3,501. The best rate is available at ₹1,599 with free shipping and cod available in hivhub.in no hidden charges.
Q3: How long do I need to take Jastinib ?
A: As long as it remains effective and side effects are manageable. Your oncologist will monitor with regular scans.
Q4: Can I take Jastinib with food?
A: Yes, but be consistent. Either always take it with a light meal or always on an empty stomach.
Q5: Does Jastinib cause hair loss?
A: Hair thinning may occur, but complete hair loss is less common compared to chemotherapy.
Q6: Can I drink coffee while taking Jastinib 5mg?
A: Moderate coffee is fine, but avoid grapefruit juice completely.
Q7: Does Jastinib 5mg affect blood pressure?
A: Yes, hypertension is a very common side effect. Monitor BP daily and report high readings.
Q8: Can Jastinib 5mg be used for other cancers?
A: It is primarily approved for kidney cancer (RCC). Other uses are off-label and only under specialist guidance.
Q9: What should I do if I have severe diarrhea?
A: Drink plenty of fluids and inform your doctor. Anti-diarrheal medicines may be prescribed.
Q10: Is Jastinib 5mg a chemotherapy drug?
A: No, it is a targeted therapy, not traditional chemotherapy.
Q11: Does Jastinib 5mg cause fatigue?
A: Yes, fatigue is common. Rest as needed but try to stay lightly active.
Q12: Can I take antacids with Jastinib 5mg?
A: Yes, no major interaction, but separate by 2 hours if possible.
Q13: What happens if I miss a dose of Jastinib 5mg?
A: If less than 6 hours late, take it. If more than 6 hours, skip and take next dose. Do not double.
Q14: Does Jastinib 5mg cause weight loss?
A: Yes, decreased appetite and weight loss are common. Eat small, frequent meals.
Q15: Can I take Jastinib 5mg with other blood pressure medicines?
A: Yes, but your doctor may need to adjust your BP meds because Jastinib raises BP.
Q16: Is it safe to take paracetamol with Jastinib 5mg?
A: Yes, paracetamol is generally safe. Avoid NSAIDs like ibuprofen unless doctor approves.
Q17: Does Jastinib 5mg affect the thyroid?
A: Yes, hypothyroidism (low thyroid) is common. Your doctor will monitor thyroid function.
Q18: Can I take Jastinib 5mg if I have a history of stroke?
A: Use with caution. Inform your doctor. Jastinib may increase risk of bleeding or blood clots.
Q19: How should I store Jastinib 5mg tablets?
A: Store at room temperature (20-25°C), away from moisture and heat. Keep bottle tightly closed.
Q20: Can I crush or split Jastinib 5mg tablets?
A: No, swallow whole. Do not crush, chew, or break the tablet.
Q21: Does Jastinib 5mg cause mouth sores?
A: Yes, stomatitis (mouth sores) can occur. Use soft toothbrush and avoid spicy foods.
Q22: Can I take Jastinib 5mg during infection or fever?
A: Inform your doctor immediately. Do not stop Jastinib without medical advice.
Q23: Does Jastinib 5mg cause hand-foot skin reaction?
A: Yes, redness, swelling, or peeling on palms and soles may occur. Moisturize regularly.
Q24: Can I take vitamin supplements with Jastinib 5mg?
A: Yes, but avoid herbal supplements like St. John’s Wort. Inform your doctor about all supplements.
Q25: When should I call my doctor immediately?
A: If you have chest pain, severe headache, vision changes, coughing blood, or sudden swelling of hands/feet.
📚 REFERENCES / SOURCES
U.S. National Library of Medicine – Axitinib
🔗 https://medlineplus.gov/druginfo/meds/a612032.htmlFDA Prescribing Information – Inlyta (Axitinib)
🔗 https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/202324s024lbl.pdfPfizer Medical Information – Axitinib
🔗 https://www.pfizermedicalinformation.com/en-us/inlytaNational Comprehensive Cancer Network (NCCN) – Kidney Cancer Guidelines
🔗 https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1440American Cancer Society – Targeted Therapy for Kidney Cancer
🔗 https://www.cancer.org/cancer/kidney-cancer/treating/targeted-therapy.htmlDrugs.com – Axitinib Information
🔗 https://www.drugs.com/axitinib.htmlWebMD – Axitinib Oral
🔗 https://www.webmd.com/drugs/2/drug-160564/axitinib-oral/detailsPubMed Central – Axitinib for Renal Cell Carcinoma
🔗 https://pubmed.ncbi.nlm.nih.gov/28605168/European Medicines Agency (EMA) – Inlyta
🔗 https://www.ema.europa.eu/en/medicines/human/EPAR/inlytaKidney Cancer Association – Treatment Options
🔗 https://www.kidneycancer.org/treatment/
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