Last Updated on July 22, 2024 by admin
Zyceva 150 Overview
Zyceva 150mg Tablet is used in the treatment of non-small cell lung cancer and pancreatic cancer.
Zyceva 150mg Tablet should be taken on an empty stomach or should be taken one hour before or 2 hour after meal. You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your needs and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, fatigue, rash, and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. It makes you sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. In case you develop ulceration in mouth, changes in your vision, or breathing difficulties than it is better to inform the doctor. Your doctor may advise for regular monitoring of liver function while you are taking this medicine.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. It is advised to quit smoking while taking this medicine as it can affect the working of the medicine. If you have to take an antacid or any other medicine, take it at a gap of at least 2 hours after taking the cancer medicine.
USES OF ZYCEVA 150
BENEFITS OF ZYCEVA 150
- In Non-small cell lung cancer
Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Zyceva 150mg Tablet helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
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SIDE EFFECTS OF ZYCEVA 150
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zyceva 150
- Abdominal pain
- Bone pain
- Breathlessness
- Constipation
- Cough
- Diarrhea
- Fatigue
- Fever
- Infection
- Muscle pain
- Nausea
- Rash
- Stomatitis (Inflammation of the mouth)
- Vomiting
- Weight loss
HOW TO USE ZYCEVA 150
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zyceva 150mg Tablet is to be taken empty stomach.
HOW ZYCEVA 150 WORKS?
A: Zyceva 150mg Tablet is an anti-cancer medication. Epidermal growth factor receptors (EGFR) are expressed on the lung cancer cell surfaces that modulate their growth. This medicine works by binding the chemical messenger, EGFR, hence, inhibits the cancer signaling pathways mediated by EGFR. This is how it restricts further growth of the cancer cells.
SAFETY ADVICE
warnings
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Zyceva 150mg Tablet. Please consult your doctor.
warnings
Pregnancy
CONSULT YOUR DOCTOR
Zyceva 150mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
warnings
Breast feeding
CONSULT YOUR DOCTOR
Zyceva 150mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
warnings
Driving
SAFE
Zyceva 150mg Tablet does not usually affect your ability to drive.
warnings
Kidney
SAFE IF PRESCRIBED
Zyceva 150mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Zyceva 150mg Tablet is recommended.
warnings
Liver
CAUTION
Zyceva 150mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Zyceva 150mg Tablet may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild to moderate liver disease.
warnings
CHILDREN CAUTION
UNSAFE
Zyceva 150mg Tablet is not recommended for use in children and adolescents below 18 years.
Zyceva 150mg Tablet Habit Forming : NO
expert advice
WHAT IF YOU FORGET TO TAKE ZYCEVA 150?
A: If you miss a dose of Zyceva 150mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
- Zyceva 150mg Tablet helps treat non-small cell lung cancer that is locally advanced, or has spread to other areas of the body.
It should be taken 1 hour before or 2 hours after the meal. - Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn’t stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective clothing while going out.
- It is advisable to avoid smoking while taking this medicine, as it makes the drug ineffective and requires dose adjustment.
- Do not take it with medication lowering the stomach acid (such as antacids, H2 blockers including ranitidine), as it may affect the working of medicine.
- Inform your doctor if you develop ulceration in your mouth, changes in your vision or if you experience a worsening cough, shortness of breath, or breathing difficulties while taking this medicine.
- Your doctor may want you to have regular blood tests to monitor your liver function while you are having treatment with this medicine.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
FOOD AND DRINK
- Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
- Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry, or seafood.
- Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
- Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
- Drink more fluids and avoid alcoholic beverages to prevent dehydration.
Wash your hands properly before and after eating. - Make sure you sleep at least 8 hours a day.
FAQs ABOUT ZYCEVA 150
Q: What is ZYCEVA 150 used for?
A: ZYCEVA 150MG TABLET is used in adults to treat non-small cell lung cancer at an advanced stage, as initial therapy (or as therapy if disease remains largely unchanged after initial chemotherapy, provided your cancer cells have specific EGFR mutations), if previous chemotherapy has not helped to stop the disease and to treat cancer of the pancreas at a metastatic stage in combination with gemcitabine.
Q: What is the mechanism of action of ZYCEVA 150?
A: ZYCEVA 150MG TABLET binds to the intracellular portion (tyrosine kinase) of the epidermal growth factor receptor (EGFR) and inhibits its activity. EGFR is expressed on the surface of both normal as well as cancer cells. Inhibition of EGFR and it’s signaling significantly decreases tumor multiplication and survival, resulting in cell death.
Q: Can ZYCEVA 150 be used in pregnant women?
A: There is no adequate data on the use of ZYCEVA 150MG TABLET in pregnant women. If you become pregnant during the treatment immediately inform your doctor who will decide if the treatment should be continued.
Q: Can ZYCEVA 150 be taken along with Statins?
A: If you are taking statins (medicines to lower your blood cholesterol), ZYCEVA 150MG TABLET may increase the risk of statin related muscle problems, which on rare occasions can lead to serious muscle breakdown (rhabdomyolysis) resulting in kidney damage, talk to your doctor before taking this medicine.
Q: Can ZYCEVA 150 be used in children?
A: ZYCEVA 150MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor for more information on this medicine before taking it.
REFERENCES:
- Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 863-886.
- Jose Ramon Gonzalez-Porras and Jose Maria Bastida. Eltrombopag in immune thrombocytopenia: efficacy review and update on drug safety. National Library of Medicine, National Center for Biotechnology information. Pubmed Central. June 2018. [Accessed on 13th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971401/
- Marco Dionisi, Sara Cairoli, Raffaele Simeoli, Francesca De Gennaro, Valeria Paganelli, Roberto Carta, Francesca Rossi, Carlo Dionisi-Vici, Giuseppe Palumbo and Bianca Maria Goffredo. Pharmacokinetic Evaluation of Eltrombopag in ITP Pediatric Patients. Journal of frontiers in pharmacology. December 2021 [Accessed on 13th May 2022] https://www.frontiersin.org/articles/10.3389/fphar.2021.772873/full
- Roche Products Limited. Electronic Medicines Compendium (EMC). [Revised in November 2022]. [Accessed on 13th May 2022] https://www.medicines.org.uk/emc/files/pil.8844.pdf
- OSI Pharmaceuticals Inc. U.S Food and Drug Administration. [Revised in October 2016] [Accessed on 13th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021743s025lbl.pdf
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